This activity will use a pattern-based approach (spindled, epithelioid, rhabdoid, myxoid patterns; low-grade versus high-grade atypia) to build differential diagnoses and emphasize selection and interpretation of the most useful, current IHC and molecular tests for each diagnostic scenario of uterine mesenchymal tumors. The faculty will highlight common pitfalls, new diagnostic tools, and features that predict response to targeted therapy; and the novel role of the pathologist in recognizing morphologic features associated with risk of a hereditary syndrome. Special issues in the diagnosis and reporting of mesenchymal tumors in endometrial biopsy, curettage, and polypectomy and their unique challenges will be addressed. Updates from the new World Health Organization (WHO) Classification of Tumors (“blue book”), of which both faculty are authors, will also be discussed.
This activity was presented at CAP21 as A Clinically Relevant, Pattern-Based Approach to Diagnosing Uterine Mesenchymal Tumors.
After completing this activity, you should be able to:
- Apply clinically relevant criteria to classify common presentations of uterine mesenchymal tumors.
- Select and interpret the most useful IHC stains and molecular tests.
- Recognize common diagnostic pitfalls in the differential diagnosis.
- Identify morphologic features associated with the risk of a hereditary syndrome.
Jennifer A. Bennett, MD
Joseph Rabban, MD, MPH
Accreditation: The College of American Pathologists (CAP) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
CME Category 1: The College of American Pathologists designates this internet enduring material educational activity for a maximum of 2.25
AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
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College of American Pathologists
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Northfield, IL 60093-2750
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This activity and evaluation are available April 18, 2022, and expire April 17, 2025, at 12:00 AM (ET). You must claim credit by this date and time.